Edith Cowan University operates across three Western Australian campus locations, comprising its headquarters in northern metropolitan Perth, a landmark vertical city campus in the central business district, and a regional footprint in the state's South West. Named after Edith Dircksey Cowan, the first woman elected to an Australian Parliament, the university delivers comprehensive qualifications across arts and humanities, business and law, education, engineering, medical and health sciences, nursing, science, technology, and performing arts.

The primary academic headquarters and largest physical site is the Joondalup Campus, situated roughly twenty-five kilometers north of Perth's central business district within the Joondalup Learning Precinct. Set amidst expansive parklands, lakes, and contemporary architectural structures, Joondalup houses the university's central administrative governance alongside major faculties in health sciences, nursing, engineering, computer science, and education. Key infrastructure across the site includes the multi-story Health and Wellness Building, advanced cyber security laboratories, specialized nursing and paramedicine simulation suites, the ECU Sport and Fitness Centre, student residential villages, and the award-winning library hub. The precinct operates in direct co-location with North Metropolitan TAFE and the Western Australia Police Academy, connected directly to central Perth via the nearby Joondalup railway line and bus interchanges.

In inner-city Perth, the university operates the flagship ECU City Campus, located directly within the Perth City Link precinct between Wellington, Roe, and Queen streets. Designed as a state-of-the-art vertical university footprint bordering Yagan Square, the city campus bridges Perth’s central commercial district with the Northbridge cultural precinct. Serving as the central home for the School of Business and Law alongside the iconic Western Australian Academy of Performing Arts, technology, and creative industries, the multi-story urban site integrates public performance venues, soundstages, broadcasting studios, digital design hubs, and flexible learning commons directly atop Perth's major central bus and train transit hubs.

Extending the university’s footprint beyond the Perth metropolitan boundary, the ECU South West Campus is located two hundred kilometers south of Perth in Bunbury. Functioning as the largest university campus in regional Western Australia, the Bunbury site delivers specialized local tertiary qualifications across nursing, health sciences, teacher education, social work, and business. The campus provides students with clinical simulation facilities, specialized science labs, regional research hubs, and on-campus student accommodation while linking to broader regional learning hubs throughout the South West corridor. Internationally, the university also maintains a purpose-built branch campus in Colombo, Sri Lanka, offering biomedical, computing, and business degrees within an integrated modern educational complex. Across all primary footprints, Edith Cowan University links modern learning environments with strategic community, industry, and public transit connections.