The University of Greenwich operates across three main campuses across London and Kent: the flagship Greenwich Campus, the Avery Hill Campus in Eltham, and the Medway Campus in Chatham Maritime. Originating from the founding of Woolwich Polytechnic in 1890, the university provides academic degree programs spanning business, liberal arts, human sciences, education, engineering, and physical sciences.

The main Greenwich Campus is set within the UNESCO World Heritage site of the Old Royal Naval College along the banks of the River Thames in South East London. Featuring classic baroque architecture designed by Sir Christopher Wren, this self-contained riverside site acts as the academic home for the Greenwich Business School and the Faculty of Liberal Arts and Sciences. Key facilities include the historic Dreadnought Building—which houses the Students' Union, teaching zones, and social hubs—alongside the Stockwell Street building, home to the campus library, film and TV studios, design spaces, and extensive living green roofs.

Located roughly four miles east, the Avery Hill Campus provides a parkland setting in the Royal Borough of Greenwich. Divided into the Southwood site and surrounded by green open spaces, Avery Hill acts as the primary hub for the Faculty of Education, Health and Human Sciences. The campus features specialized nursing and clinical simulation suites, sports science labs, a multi-purpose sports hall, and extensive student accommodation villages.

Further east in Kent, the Medway Campus occupies a historic 19th-century naval site at Chatham Maritime, operated as a shared educational facility with local university partners. Dedicated primarily to the Faculty of Engineering and Science, Medway combines historic redbrick architecture—such as the landmark Grenville and Blake buildings—with advanced engineering laboratories, computing suites, and the joint Student Hub. Connected by dedicated university shuttle bus services, the three campuses blend landmark historic settings with modern, practical learning facilities.